Brandt, Joyce Zalotti [UNESP]Silveira, Livia Teresa R. [UNESP]Grassi, Tony Fernando [UNESP]Anselmo-Franci, Janete A.Favaro, Wagner JoseFelisbino, Sergio Luis [UNESP]Barbisan, Luis Fernando [UNESP]Scarano, Wellerson Rodrigo [UNESP]2014-12-032014-12-032014-01-01Reproductive Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 43, p. 56-66, 2014.0890-6238http://hdl.handle.net/11449/112670Bisphenol A (BPA) is a chemical that has been investigated for it potential to cause prostate diseases. In this study, pregnant Sprague-Dawley rats were treated with 25 or 250 mu g/kg BPA from gestational day (GD) 10 to GD21 with or without concurrent indole-3-carbinol (I3C) feeding. I3C is a phytochemical, and it affords chemoprotection against many types of neoplasia. Male F1 rats from different litters were euthanized on post-natal day (PND) 21 and PND180. BPA-treated groups showed a significant increase in histopathological lesions, but I3C feeding reversed many of these changes, mainly at PND180. Maternal I3C feeding increased prostate epithelial apoptosis in the BPA-treated groups and across age groups. Furthermore, I3C induced partial normalization of the prostate histoarchitecture. The results pointed to a protective effect of maternal I3C feeding during pregnancy in the BPA-exposed male offspring, thereby indicating reduction in the harmful effects of gestational BPA imprinting on the prostate. (C) 2013 Elsevier Inc. All rights reserved.56-66engBisphenol AProstateInflammationIndole-3-carbinolChemopreventionReproductive toxicologyArtigo10.1016/j.reprotox.2013.11.001WOS:000331028900008Acesso restrito726349091893487432785281126522573713732996827351