Bighetti, Ana Carolina CestariCestari, Tania MarySantos, Paula SanchesArantes, Ricardo Vinicius NunesPaini, SuelenAssis, Gerson FranciscoCosta, Bruna Carolina [UNESP]de Oliveira, Flávia AmadeuTokuhara, Cintia Kazukode Oliveira, Rodrigo CardosoTaga, Rumio2019-10-062019-10-062019-01-01Journal of Biomedical Materials Research - Part B Applied Biomaterials.1552-49811552-4973http://hdl.handle.net/11449/189704In this work, bone formation/remodeling/maturation was correlated with the presence of multinucleated giant cells (MGCs)/osteoclasts (tartrate-resistant acid phosphatase [TRAP]-positive cells) on the surface of beta-tricalcium phosphate (β-TCP), sintered deproteinized bovine bone (sDBB), and carbonated deproteinized bovine bone (cDBB) using a maxillary sinus augmentation (MSA) in a New Zealand rabbit model. Microtomographic, histomorphometric, and immunolabeling for TRAP-cells analyses were made at 15, 30, and 60 days after surgery. In all treatments, a faster bone formation/remodeling/maturation and TRAP-positive cells activity occurred in the osteotomy region of the MSA than in the middle and submucosa regions. In the β-TCP, the granules were rapidly reabsorbed by TRAP-positive cells and replaced by bone tissue. β-TCP enabled quick bone regeneration/remodeling and full bone and marrow restoration until 60 days, but with a significant reduction in MSA volume. In cDBB and sDBB, the quantity of TRAP-positive cells was smaller than in β-TCP, and these cells were associated with granule surface preparation for osteoblast-mediated bone formation. After 30 days, more than 80% of granule surfaces were surrounded and integrated by bone tissue without signs of degradation, preserving the MSA volume. Overall, the materials tested in a standardized preclinical model led to different bone formation/remodeling/maturation within the same repair process influenced by different microenvironments and MGCs/osteoclasts. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res B Part B, 2019.engbioresorptionbone regenerationcalcium phosphate materialsmaxillary sinus augmentationX-ray microtomographyArtigo10.1002/jbm.b.34388Acesso restrito2-s2.0-85064670095