Gabbai-Armelin, Paulo Roberto [UNESP]de Oliveira, Analú Barros [UNESP]Ferrisse, Túlio Morandin [UNESP]Sales, Luciana Solera [UNESP]Barbosa, Elis Rodrigues Oliveira [UNESP]Miranda, Marina Lins [UNESP]Salomão, Karina Borges [UNESP]Brighenti, Fernanda Lourenção [UNESP]2021-06-252021-06-252021-01-01European Journal of Clinical Investigation.1365-23620014-2972http://hdl.handle.net/11449/206207Background: COVID-19 is an infectious disease caused by SARS-CoV-2 associated with haematological manifestations (thrombolytic events). Aims: Considering the high prevalence of the thrombotic scenarios associated with COVID-19, the aim of this study was to perform a systematic review of the available literature, concerning the relation of COVID-19 and the thrombotic events, and identify prognostic factors for these events. Materials & Methods: PubMed, Web of Science and Scopus databases were searched. Independent reviewers conducted all flow diagram steps. For qualitative analysis, Oxford level of evidence and Newcastle-Ottawa scale were used in the eligible articles. For the prognostic factors, a meta-analysis was conducted to age, number of neutrophils and platelets, and levels of ferritin, C-reactive protein, lactate dehydrogenase and D-dimer. Publication bias was accessed by funnel plot and by trim-and-fill test. Trim-and-fill test was also applied to evaluate meta-analysis bias. Results: Twenty articles were included in the qualitative analysis, and 6 articles were included in the meta-analysis. Case-control studies showed bias related to exposure, and the main bias in cohort studies were related to selection and outcome. All articles received score 4 for the level of evidence. Hypertension and diabetes were the comorbidities more frequently associated with thrombolytic events. Significant results were found regarding D-dimer (P <.0001) and age (P =.0202) for thrombotic events in patients diagnosed with COVID-19. Conclusion: Patients older than 60 years, with hypertension, diabetes and D-Dimer values above 3.17 µg/mL, can be considered prognostic factors for developing thrombotic events due to COVID-19.engCOVID-19D-dimermeta-analysisprognostic factorsSARS-CoV-2systematic reviewthrombosisResenha10.1111/eci.135592-s2.0-85104330871