da Silva, Ana KarinaDel Carlo, Ricardo Junqueirada Matta, Sérgio Luis PintoLouzada, Mario Jefferson QuirinoRodrigues, Aurora Corrêada Silva, Márcia FerreiraDrummond, Lucas Riosde Castro, Cynthia AparecidaSilva, Carlos Henrique OsorioNatali, Antônio José2022-04-282022-04-282014-12-01International SportMed Journal, v. 15, n. 4, p. 445-457, 2014.1528-3356http://hdl.handle.net/11449/220426Background: While type 1 diabetes mellitus (T1DM) increases bone fragility physical exercise improves bone quality and strength. Research question: To test whether swimming training attenuates the deterioration of femoral neck structural and mechanical properties in growing rats with untreated streptozotocin (STZ)-induced T1DM. Type of study: Randomised controlled study. Methods: Male Wistar rats (4-weeks-old; initial body weight: 80-90 g) were divided into 4 groups of 10 animals: diabetes sedentary (DS; 60 mg/kg of STZ, single i.p.); diabetes exercised (DE; 60 mg/kg of STZ, single i.p.); control sedentary (CS, same single dose of vehicle); and control exercised (CE, same single dose of vehicle). Six weeks later animals from DE and CE groups underwent a low- intensity swimming training (5 sessions/wk, 90 min/session, load: 4% of body weight) for 8 weeks. The femoral neck mechanical properties were measured. Bone mineral density (BMD) and mineral content (BMC), as well as the femoral neck bone volume (BV/TV) and collagen content were assessed. Results: Rats with T1DM exhibited reduced body weight, femoral weight and length, BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, maximum load, stiffness and tenacity, and increased trabecular spacing compared to controls. Swimming training increased femoral BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, stiffness and yield point energy, and reduced trabecular spacing in control animals, but not in T1DM animals. Conclusion: Low-intensity swimming training seems to be ineffective in attenuating the deterioration of the femoral neck structural and mechanical properties in growing rats with untreated STZ-induced T1DM.445-457engBone resistanceExerciseHip fractureOsteopeniaPhysical activityArtigo2-s2.0-84939250656