Chiba, Fernando Yamamoto [UNESP]Colombo, Natalia Helena [UNESP]Shirakashi, Daisy Jaqueline [UNESP]de Souza Gomes, Wendrew Douglas [UNESP]Moimaz, Suzely Adas Saliba [UNESP]Garbin, Clea Adas Saliba [UNESP]Silva, Cristina Antoniali [UNESP]Sumida, Doris Hissako [UNESP]2013-09-302014-05-202013-09-302014-05-202010-01-01Fluoride. Ocean View: Int Soc Fluoride Research, v. 43, n. 1, p. 25-30, 2010.0015-4725http://hdl.handle.net/11449/14984With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance.25-30engFluorideInsulin receptor substrateInsulin sensitivityInsulin signalRats and insulinArtigoWOS:000278509600005Acesso aberto27994730730306936656433539493879827540168870234344191585257096860000-0001-5069-8812