Santos, André L. [UNESP]Takeuchi, Regina M. [UNESP]Mariotti, Marcela P. [UNESP]De Oliveira, Marcelo F. [UNESP]Zanoni, Maria Valnice Boldrin [UNESP]Stradiotto, Nelson Ramos [UNESP]2014-05-272014-05-272005-08-01Farmaco, v. 60, n. 8, p. 671-674, 2005.0014-827Xhttp://hdl.handle.net/11449/68350In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E 1/2 = 0.99:V vs. Ag/AgCl sat, when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51 ± 0.07) ± 10 -5:cm:s -1, with a αn a value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 ± 10 -5 to 1.0 ± 10 -2:mol:l -1 range, being obtained a detection limit of 2.4 ± 10 -5:mol:l -1. Proposed methodology was applied to ABZ quantification in pharmaceutical formulations. © 2005 Elsevier SAS. All rights reserved.671-674engAlbendazoleGlassy carbonRotating disk electrodeVoltammetric determinationalbendazolecarbonsilver chloridedrug formulationelectrochemical analysiselectrodekineticsmethodologyoxidationpotentiometryCarbonElectrochemistryElectrodesGlassOxidation-ReductionPharmaceutical PreparationsRotationArtigo10.1016/j.farmac.2005.05.004Acesso restrito2-s2.0-2394449017600721730180057120000-0002-2296-1393