Salvadori, Daisy Maria Favero [UNESP]Ribeiro, Lúcia Regina [UNESP]Xiao, Y.Boei, J. J.Natarajan, A. T.2014-05-202014-05-201996-09-23Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 356, n. 2, p. 163-170, 1996.0027-5107http://hdl.handle.net/11449/37895In the present paper, the protective effect of beta-carotene was evaluated after whole body exposure of mice to 2 Gy of X-rays. Splenocytes, reticulocytes, bone marrow cells and spermatids were evaluated for the frequency of micronuclei (MN) induced by X-rays. Mice were treated (gavage) with beta-carotene (10, 25 and 50 mg/kg b.w.) for 5 consecutive days and, 4 h after the last treatment, the animals were irradiated. The results obtained showed different frequencies of X-ray-induced-MN between different cell populations analysed and also different response of these cells to the beta-carotene treatment. The radioprotective effect of beta-carotene was observed in splenocytes, reticulocytes, and spermatids but not in bone marrow cells. No dose-response relationship for beta-carotene was detected. The time of sampling, the sensitivity of the cells as well as the antioxidant activity of beta-carotene are discussed as important factors for the radioprotective action of this provitamin.163-170engbeta-caroteneradioprotectorsantimutagenicitymicronucleusArtigo10.1016/0027-5107(96)00040-1WOS:A1996VJ55900005Acesso restrito5051118752980903