de Moraes, Augusto César Ferreira [UNESP]Carvalho, Heráclito BarbosaRey-López, Juan PabloGracia-Marco, LuisBeghin, LaurentKafatos, AnthonyJiménez-Pavón, DavidMolnar, DénesDe Henauw, StefaanManios, YannisWidhalm, KurtRuiz, Jonatan R.Ortega, Francisco B.Sjöström, MichaelPolito, AngelaPedrero-Chamizo, RaquelMarcos, AscensiónGottrand, FredericMoreno, Luis A.2014-05-272014-05-272013-05-01PLoS ONE, v. 8, n. 5, 2013.1932-6203http://hdl.handle.net/11449/75276Objectives: To examine the independent and combined association of physical activity (PA) and sedentary behavior (SB) on both systolic (SBP) and diastolic blood pressure (DBP) in adolescents from two observational studies. Methods: Participants from two cross-sectional studies, one conducted in Europe (n = 3,308; HELENA study) and the other in Brazil (n = 991; BRACAH study), were selected by complex sampling. Systolic and diastolic blood pressure (outcomes), PA and SB, both independently and combined, and potential confounders were analyzed. Associations were examined by multilevel linear regression. Results: Performing the recommended amount of PA (≥60 min/d) attenuated the effect of SB on DBP in BRACAH study girls and in boys from both studies. In contrast, PA did not attenuate the effects of SB on the SBP of girls in the HELENA study. The combination of less than recommended levels of PA with 2-4 h/d of sedentary behavior was found to be associated with increased SBP in boys from both studies. Conclusions: Meeting current PA recommendations could mediate the association between SB and DBP in both sexes. In boys, the joint effect of low levels of PA and excessive sedentary activity increases SBP levels. Longitudinal studies are required to confirm these findings. © 2013 de Moraes et al.engadolescentadolescent healthblood pressure measurementcorrelational studycross-sectional studydiastolic blood pressuredisease associationfemalehumanhypertensionmajor clinical studymalemultiple linear regression analysisobservational studyphysical activitypopulation researchsedentary lifestylesex differencesystolic blood pressureArtigo10.1371/journal.pone.0062006WOS:000319167000025Acesso aberto2-s2.0-848770388872-s2.0-84877038887.pdf