Dias, Fabricio C.Castelli, Erick C. [UNESP]Collares, Cristhianna V. A.Moreau, PhilippeDonadil, Eduardo A.2015-10-212015-10-212015-02-02Frontiers In Immunology. Lausanne: Frontiers Research Foundation, v. 6, p. 1-10, 2015.1664-3224http://hdl.handle.net/11449/128368Considering that the non-classical HLA-G molecule has well-recognized tolerogenic properties, HLA-G expression is expected to be deleterious when present in tumor cells and in cells chronically infected by viruses, whereas HLA-G expression is expected to be advantageous in autoimmune disorders. The expression of HLA-G on tissue or peripheral blood cells, the levels of soluble HLA-G and polymorphic sites along the gene have been studied in several disorders. In this study, we revised the role of the molecule and polymorphic sites along the HLA-G gene in tumors, viral hepatitis, and parasitic disorders. Overall, several lines of evidence clearly show that the induction of HLA-G expression in tumors has been associated with worse disease outcome and disease spread. In addition, the few studies conducted on hepatitis and parasitic disorders indicate that HLA-G may contribute to disease pathogenesis. Few isolated polymorphic sites, primarily located at the coding or 3'untranslated HLA-G region, have been evaluated in these disorders, and a complete HLA-G typing together with the study of gene regulatory elements may further help on the understanding of the influence of the genetic background on disease susceptibility.1-10engHLA-GTumorsViral hepatitisParasitic disordersPolymorphismResenha10.3389/fimmu.2015.00009WOS:000354758800001Acesso abertoWOS000354758800001.pdf