Oliveira Alves, Monica Ghislaine [UNESP]Delgado, Adriana da Mota [UNESP]Balducci, Ivan [UNESP]Carvalho, Yasmin Rodarte [UNESP]Rodrigues Cavalcante, Ana Sueli [UNESP]Almeida, Janete Dias [UNESP]2015-03-182015-03-182014-11-01Archives Of Dermatological Research. New York: Springer, v. 306, n. 9, p. 837-841, 2014.0340-3696http://hdl.handle.net/11449/116263Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal-Wallis and Dunn's tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3-1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3-1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.837-841engActinic cheilitisSquamous cell carcinomaImmunohistochemistryProto-Oncogene Proteins c-mdm2SUMO-1 proteinArtigo10.1007/s00403-014-1500-8WOS:000344168300007Acesso restrito696736911979215189877359166953289514297710569236