Francisqueti-Ferron, Fabiane Valentini [UNESP]Togneri Ferron, Artur Junio [UNESP]Garcia, Jessica Leite [UNESP]Vagula de Almeida Silva, Carol Cristina [UNESP]Costa, Mariane Rovero [UNESP]Gregolin, Cristina Schmitt [UNESP]Moreto, Fernando [UNESP]Ferreira, Ana Lucia A. [UNESP]Minatel, Igor Otavio [UNESP]Correa, Camila Renata [UNESP]2019-10-042019-10-042019-07-01International Journal Of Molecular Sciences. Basel: Mdpi, v. 20, n. 13, 14 p., 2019.1422-0067http://hdl.handle.net/11449/184586The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.14engNrf2age-related disordersoxidative stressResenha10.3390/ijms20133208WOS:000477041100096Acesso aberto