Celestrin, Carolina P. [UNESP]Rocha, Guilherme Z. [UNESP]Stein, Angelica M. [UNESP]Guadagnini, DiozeTadelle, Rafael M. [UNESP]Saad, Mario J. A.Oliveira, Alexandre G. [UNESP]2020-12-102020-12-102020-08-26European Review Of Aging And Physical Activity. Heidelberg: Springer Heidelberg, v. 17, n. 1, 10 p., 2020.1813-7253http://hdl.handle.net/11449/197232Background Human aging has innumerable health implications, including loss of muscle mass and increased circulating inflammatory markers. Resistance exercise in the elderly can prevent muscle mass loss and improve the inflammatory profile. Conversely, detraining can reverse this picture. Thus, there is a strong need for studies with the elderly population to clarify the real impacts of a training interruption. Therefore, the objective of this study was to analyze the inflammatory profile of resistance trained elderly women after 4 weeks of detraining. Methods Seventeen elderly women with regular participation in an exercise program participated in the study. Body mass index (BMI), physical activity level assessments, total cholesterol and its fractions, triglycerides, glycemia and insulin blood levels, IL-1 beta, IL-4, IL-6, IL-10, IL-13, TNF-alpha, IFN gamma, and MCP-1 were assessed before and after the detraining protocol. Results The 4 week detraining period decreased physical fitness without altering body mass and BMI.The short detraining period was able to induce some metabolic disturbances in elderly women who regularly participate in a program of strength training, such as increasing HOMA-IR (0.72 +/- 0.14 to 0.81 +/- 0.23;p = 0.029), and increasing total blood cholesterol (178.21 +/- 23.64 to 220.90 +/- 64.98 mg/dL;p = 0.008) and LDL fraction (111.79 +/- 21.09 to 155.33 +/- 60.95 mg/dL;p = 0.048). No alteration in levels of inflammatory cytokines was observed, however, this detraining period significantly reduced IL-13 (44.84 +/- 100.85 to 35.84 +/- 78.89 pg/mL;p = 0.031) a Th2 cytokine that induces M2 macrophage polarization. Conclusions These data demonstrate that even a short period of detraining is harmful for elderly women who regularly participate in a program of strength training, since it impairs physical performance, insulin sensitivity and cholesterol metabolism.10engAgingInflammationPhysical exerciseArtigo10.1186/s11556-020-00244-8WOS:000563148200001