Almeida, Ana Paula de [UNESP]Avi, Camilla Martins [UNESP]Barbisan, Luis Fernando [UNESP]Moura, Nelci Antunes de [UNESP]Caetano, Brunno Felipe Ramos [UNESP]Romualdo, Guilherme Ribeiro [UNESP]Sivieri, Katia [UNESP]2016-01-282016-01-282015Food Research International, v. 74, p. 48-54, 2015.0963-9969http://hdl.handle.net/11449/133693The modifying effects of aqueous yacon extract (AYE) and Lactobacillus acidophilus CRL 1014 against colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats were investigated. Animals were allocated into five groups: G1: untreated group; G2: DMH-treated group; G3: DMH + L. acidophilus-treated group; G4: DMH + AYE-treated group; G5: DMH + L. acidophilus and AYE-treated group. A significant reduction (p < 0.05) in leukocyte DNA damage and in colonic cell proliferation was observed after the first DMH administration in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. In this moment, a significant increase (p < 0.05) in colonic apoptosis was also observed in G3 (probiotic) and G5 (synbiotic) groups. In special, at five months after DMH administrations, a significant reduction (p < 0.05) in ACF development was observed in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. Incidence of colon tumors was lower at five months in G4 (prebiotic) and G5 (synbiotic) groups but not in eight months after DMH administrations. In conclusion, the findings suggest that the oral treatments have potential effects as a chemopreventive agent against colon carcinogenesis on an early stage of tumor development.48-54engChemical carcinogenesisColonPrebioticProbioticSynbioticArtigo10.1016/j.foodres.2015.04.034Acesso restrito88745347906124173278528112652257