Stein, Angelica Miki [UNESP]Silva, Thays Martins Vital [UNESP]Coelho, Flávia Gomes de Melo [UNESP]Arantes, Franciel José [UNESP]Costa, José Luiz Riani [UNESP]Teodoro, ElizabethSantos-Galduróz, Ruth Ferreira2018-12-112018-12-112018-04-01Dementia e Neuropsychologia, v. 12, n. 2, p. 114-122, 2018.1980-5764http://hdl.handle.net/11449/179971One of hypothetical mechanisms related to cognition is exercise-induced IGF-1. Objective: The aim of this study was to analyze the effects of exercise on IGF-1 levels and cognition in the elderly. Methods: The article searches were conducted on Pubmed, Web of Science, PsycINFO and Scielo databases and reviewed according to PRISMA guidelines. The inclusion criteria were: [1] original articles published up to 2017; [2] samples including elderly; [3] protocols including physical exercise; [4] longitudinal studies having exercise as main outcome; [5] assessment of IGF-1; [6] cognition assessment. Results: Seven studies were included in this review. Three of the studies showed an exercise-induced increase in IGF-1; three found stable IGF-1 levels and one found a reduction in IGF-1; with and without improvement in cognition. Conclusion: Disparities in the type of physical exercise, protocols and samples under different conditions hinder the establishment of a consensus on IGF-1, cognition and physical exercise.114-122engCognitionExerciseOlder adultsArtigo10.1590/1980-57642018dn12-020003S1980-57642018000200114Acesso aberto2-s2.0-85048822677S1980-57642018000200114.pdf