Rodrigues, Eliana [UNESP]Delbem, Alberto Carlos Botazzo [UNESP]Pedrini, Denise [UNESP]Cavassan, Luciana [UNESP]2014-05-272014-05-272010-12-01Brazilian Dental Journal, v. 21, n. 5, p. 446-451, 2010.0103-64401806-4760http://hdl.handle.net/11449/72082This study proposes a pH-cycling model for verifying the dose-response relationship in fluoride-releasing materials on remineralization in vitro. Sixty bovine enamel blocks were selected for the surface microhardness test (SMH 1). Artificial caries lesions were induced and surface microhardness test (SMH 2) was performed. Forty-eight specimens were prepared with Z 100, Fluroshield, Vitremer and Vitremer 1/4 diluted - powder/liquid, and subjected to a pH-cycling model to promote remineralization. After pH-cycling, final surface microhardness (SMH 3) was assessed to calculate percent recovery of surface microhardness (%SMH R). Fluoride present in enamel (μg F/mm 3) and in the pH-cycling solutions (μg F) was measured. Cross-sectional microhardness was used to calculate mineral content (ΔZ). There was no significant difference between Z 100 and control groups on analysis performed on - %SMH R, ΔZ, μ F and μ F/mm 3 (p>0.05). Results showed a positive correlation between %SMH R and μg F/mm 3 (r=0.9770; p=0.004), %SMH R and μg F (r=0.9939; p=0.0000001), DZ and μg F/mm 3 (r=0.9853; p=0.0002), ΔZ and μg F (r=0.9975; p=0.0000001) and between μg F/mm 3 and μg F (r=0.9819; p=0.001). The pH-cycling model proposed was able to verify in vitro dose-response relationship of fluoride-releasing materials on remineralization.446-451engDental materialsFluorideTooth remineralizationanticaries agentbiomedical and dental materialsbisphenol A bis(2 hydroxypropyl) ether dimethacrylatefissure sealantfluorideFluoroshieldglass ionomermineralpolyurethanresinsilicon dioxideVitremerZ100 composite resinzirconiumanimalcattlechemistrydental caredental cariesdose responsedrug effectenamelhardnessmethodologypathologypathophysiologypHtooth diseaseAnimalsBisphenol A-Glycidyl MethacrylateCariostatic AgentsCattleComposite ResinsDental CariesDental EnamelDental MaterialsDose-Response Relationship, DrugFluoridesGlass Ionomer CementsHardnessHydrogen-Ion ConcentrationMineralsPit and Fissure SealantsPolyurethanesSilicon DioxideTooth DemineralizationTooth RemineralizationZirconiumArtigo10.1590/S0103-64402010000500012S0103-64402010000500012Acesso aberto2-s2.0-786507585192-s2.0-78650758519.pdf0000-0002-8159-4853