Schmidt, Elizabeth Moreira dos Santos [UNESP]Thomazini, Camila Martos [UNESP]Moraes, Lívia Fagundes [UNESP]Dias, Rafael Grobério Souto [UNESP]Reis, Rafael de Oliveira [UNESP]Takahira, Regina Kiomi [UNESP]Lopes, Raimundo Souza [UNESP]Fagliari, José Jurandir [UNESP]Silva, Paulo César da [UNESP]2016-07-072016-07-072011Veterinary Clinical Pathology, v. 41, n. 1, p. 585-586, 2011.0275-6382http://hdl.handle.net/11449/140555Acute phase proteins (APPs) are considered sensitive markers ofinflammation especially in large animals. In this study we deter-mined the profile of acute phase proteins in parasitic diseases using22 Nellore cattle. They were naturally infected with Fasciola hepat-ica and strongylids, which included 70% Cooperia sp., 22%Oesophagostomum sp., 7% Haemonchus sp. and 1% Trichostrongylus sp. by egg count per gram and coprocultures. Serum concentra-tions of acute phase proteins were determined by means of sodiumdodecyl sulphate-polycrylamide gel electrophoresis. Increaseswere observed in concentrations of IgG 4,083  1,034 mg/dL(maximum of 6,765 mg/dL), ceruloplasmin 78.9  22.7 mg/dL(maximum of 119.7 mg/dL – 10 times fold), transferrin 361 114.4 mg/dL, haptoglobin 22.8  14.8 mg/dL (maximum of66.7 mg/dL – 3 times fold), and a1-acid glycoprotein 11.3 5.7 mg/dL (maximum of 24.1 – 2 times fold). The liver enzymesAST and GGT were also increased at 132.2  33 UI/L (maximum of199.5 UI/L) and 282.8  156.6 UI/L (maximum of 650 UI/L). Se-rum total protein, IgA, albumin, and non-nominal identified pro-tein of 23 kD were not significantly increased (P 4 0.05). Theincreases in serum AST, GGT, and the acute phase proteins (cer-uloplasmin, haptoglobin, a1-acid glycoprotein, and specially IgG)demonstrate acute hepatic inflammation mainly caused by Fasciolahepatica. Otherwise, the other parasites may also contribute to thechanges in the acute phase protein concentrations.585-586engArtigo10.1111/j.1939-165X.2011.00348.xAcesso restrito2899895473321703351782541017881392904592614743980000-0003-3323-41990000-0001-5898-2914