Chagas Vinhote, Juliana FreireLima, Danya BandeiraPessoa Bezerra de Menezes, Ramon Roseo PaulaMello, Clarissa PerdigaoSouza, Bibiana Monson de [UNESP]Havt, AlexandrePalma, Mario Sergio [UNESP]Santos, Ricardo Pires dosAlbuquerque, Eudenilson Lins deFreire, Valder NogueiraCosta Martins, Alice Maria2018-11-282018-11-282017-10-01Toxicon. Oxford: Pergamon-elsevier Science Ltd, v. 137, p. 168-172, 2017.0041-0101http://hdl.handle.net/11449/165808Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved.168-172engAntiparasitic agentsMolecular dockingWasp venomMastoparanArtigo10.1016/j.toxicon.2017.08.002WOS:000411542300025Acesso abertoWOS000411542300025.pdf2901888624506535