De Carvalho, Flavia GioloBrandao, Camila Fernanda CunhaBatitucci, Gabriela [UNESP]Souza, Anderson de OliveiraFerrari, Gustavo DuarteAlberici, Luciane CarlaMuñoz, Vitor RosettoPauli, José RodrigoDe Moura, Leandro PereiraRopelle, Eduardo Rocheteda Silva, Adelino Sanchez RamosJunqueira-Franco, Marcia Varella MorandiMarchini, Julio Sergiode Freitas, Ellen Cristini [UNESP]2021-06-252021-06-252021-04-01Clinical Nutrition, v. 40, n. 4, p. 2180-2187, 2021.1532-19830261-5614http://hdl.handle.net/11449/206662Purpose: To evaluate the effects of taurine supplementation associated or not with chronic exercise on body composition, mitochondrial function, and expression of genes related to mitochondrial activity and lipid oxidation in the subcutaneous white adipose tissue (scWAT) of obese women. Methods: A randomized and double-blind trial was developed with 24 obese women (BMI 33.1 ± 2.9 kg/m2, 32.9 ± 6.3 y) randomized into three groups: Taurine supplementation group (Tau, n = 8); Exercise group (Ex, n = 8); Taurine supplementation + exercise group (TauEx, n = 8). The intervention was composed of 3 g of taurine or placebo supplementation and exercise training for eight weeks. Anthropometry, body fat composition, indirect calorimetry, scWAT biopsy for mitochondrial respiration, and gene expression related to mitochondrial activity and lipid oxidation were assessed before and after the intervention. Results: No changes were observed for the anthropometric characteristics. The Ex group presented an increased resting energy expenditure rate, and the TauEx and Ex groups presented increased lipid oxidation and a decreased respiratory quotient. Both trained groups (TauEx and Ex) demonstrated improved scWAT mitochondrial respiratory capacity. Regarding mitochondrial markers, no changes were observed for the Tau group. The TauEx group had higher expression of CIDEA, PGC1a, PRDM16, UCP1, and UCP2. The genes related to fat oxidation (ACO2 and ACOX1) were increased in the Tau and Ex groups, while only the TauEx group presented increased expression of CPT1, PPARa, PPARγ, LPL, ACO1, ACO2, HSL, ACOX1, and CD36 genes. Conclusion: Taurine supplementation associated with exercise improved lipid metabolism through the modulation of genes related to mitochondrial activity and fatty acid oxidation, suggesting a browning effect in the scWAT of obese women.2180-2187engExerciseMitochondrial metabolismTaurineWhite adipose tissueArtigo10.1016/j.clnu.2020.09.0442-s2.0-85092534783