Moraes, R. N.Macari, Marcos [UNESP]Pela, I. R.2014-05-272014-05-271985-12-01Biology of the Neonate, v. 48, n. 5, p. 307-312, 1985.0006-3126http://hdl.handle.net/11449/63733The febrile response of newborn pigs to exogenous pyrogen injection was investigated. Lipopolysacharides (LPS, E coli) were injected intravenously into the superior vena cava of 1-30-day-old piglets. All the experiments were carried out in littermates half of which were injected with pyrogen and half with pyrogen-free saline. Newborn pigs did not develop a febrile response from 1 to 4 days of age; however, when the animals were 5 days old exogenous pyrogen determined a typical monophasic febrile response. A second intravenous injection of pyrogen into newborn pigs (1 day old) 24 h after the first did not raise body temperature. It is suggested that newborn pigs behave like the newborn of other mammalian species regarding endotoxin-induced thermogenesis.307-312engendotoxinlipopolysaccharidepyrogenanimal experimentfevernewbornnonhumanpriority journalswinethermogenesisAgingAnimalAnimals, NewbornEscherichia coliFeverKineticsLipopolysaccharidesSupport, Non-U.S. Gov'tSwineArtigo10.1159/000242185Acesso restrito2-s2.0-00223771845713558572926669