Colombari, Eduardo [UNESP]Saad, W. A.Camargo, LADRenzi, Antonio [UNESP]Deluca, L. A.Menani, José Vanderlei [UNESP]2014-05-202014-05-201992-02-14Brain Research. Amsterdam: Elsevier B.V., v. 572, n. 1-2, p. 172-175, 1992.0006-8993http://hdl.handle.net/11449/34405In the present study we investigated the effect of anteroventral third ventricle (AV3V) lesion on pressor, dipsogenic, natriuretic and kaliuretic responses induced by the injection of carbachol (a cholinergic agonist) into the medial septal area (MSA) of rats. Male rats with sham or AV3V lesion and a stainless-steel cannula implanted into the MSA were used. Carbachol (2 nmol) injected into the MSA in sham lesion rats produced pressor (43 +/- 2 mmHg), dipsogenic (9.6 +/- 1.2 ml/h), natriuretic (531 +/- 82-mu-Eq/120 min) and kaliuretic (164 +/- 14-mu-Eq/120 min) responses. In AV3V-lesioned rats (1-5 days and 14-18 days), the pressor (11 +/- 2 mmHg, respectively), dipsogenic (1.9 +/- 0.7 and 1.4 +/- 0.6 ml/h), natriuretic (21 +/- 5 and 159 +/- 44-mu-Eq/120 min) and kaliuretic (124 +/- 14 and 86 +/- 13-mu-Eq/120 min) responses induced by carbachol injection into the MSA were reduced. These results show that the AV3V region is essential for the pressor, dipsogenic, natriuretic and kaliuretic responses induced by cholinergic activation of the MSA in rats.172-175engARTERIAL PRESSUREWATER INTAKEFLUID BALANCEELECTROLYTE BALANCEAV3V REGIONHYPOTHALAMUSSEPTAL AREAArtigo10.1016/0006-8993(92)90466-MWOS:A1992HE98800024Acesso restrito454445009242742665512369362956971023597870118105