Saad-Hossne, Rogério [UNESP]Prado, René Gamberini [UNESP]Hossne, William Saad [UNESP]2014-05-272014-05-272006-05-01Acta Cirurgica Brasileira, v. 21, n. 3, p. 151-154, 2006.0102-86501678-2674http://hdl.handle.net/11449/68871Purpose: To analyze, in vitro, the effects of acetylsalicylic acid (aspirin) and acetic acid solutions on VX2 carcinoma cells in suspension and to examine the correlation between these effects and neoplastic cell death. Methods: The VX2 tumor cells (107 cells/ml) were incubated in solutions containing differing concentrations (2.5% and 5%) of either acetylsalicylic acid or acetic acid, or in saline solution (controls). Every five minutes, cell viability was tested (using the trypan blue test) and analyzed under light microscopy. Results: Tumor cell viability (in %) decreased progressively and, by 30 minutes, neoplastic cell death had occurred in all solutions. Conclusion: Based on this experimental model and the methodology employed, we conclude that these solutions cause neoplastic cell death in vitro.151-154engAcetic acidAspirinCarcinomaIn vitroacetic acidacetylsalicylic acidbicarbonatesodium chloridetrypan blueanimal cellcarcinoma cellcell deathcell suspensioncell viabilitycontrolled studycorrelation analysisdrug blood levelin vitro studyincubation timemicroscopynonhumanAcetic AcidAnimalsCell DeathCell SurvivalDrug CombinationsDrug Screening Assays, AntitumorIndicators and ReagentsMicroscopy, FluorescenceNeoplasms, ExperimentalRabbitsArtigo10.1590/S0102-86502006000300006S0102-86502006000300006Acesso aberto2-s2.0-337449100622-s2.0-33744910062.pdf