Sato, Ana ClaudiaAndrade, Sonia A.Brito, Marlon V.Miranda, AntonioSampaio, Misako UemuraMaffei, Francisco Humberto de Abreu [UNESP]Vilela Oliva, Maria Luiza2014-05-202014-05-202012-05-01Protein and Peptide Letters. Sharjah: Bentham Science Publ Ltd, v. 19, n. 5, p. 501-508, 2012.0929-8665http://hdl.handle.net/11449/11141Passion fruit (Passiflora edulis Sims f. flavicarpa) is popularly known for its sedative and calming properties and is consumed as a fresh fruit or as a juice. The clinical observation of blood incoagulability associated with excessive consumption of passion fruit juice, in a patient treated with warfarin, prompted the current study to investigate in vitro the presence of blood clotting inhibitors in Passiflora edulis Sims f. flavicarpa extract. After purification process, two compounds of distinct molecular weight and inhibitory action were better characterized. One is a trypsin inhibitor similar to inhibitors from Bowman-Birk family, named PeTI-I12, and other is a compound active in coagulation that prolongs aPTT and PT, but does not change TT. The aim of this study is to provide evidence that passion fruit extract's components play a role on hemostasis and therefore may be relevant in the handling of patients treated with anticoagulants or suffering hemorrhagic diseases.501-508engaPTTblood coagulationBowman-Birk inhibitorPassiflora edulispassion fruitPassifloraceaetrypsin inhibitorwarfarinArtigoWOS:000303311100004Acesso restrito