Damazo, A. S. [UNESP]Flower, R. J.Solito, E.Oliani, S. M. [UNESP]2014-05-202014-05-202008-03-01Inflammation Research. Basel: Birkhauser Verlag Ag, v. 57, n. 3, p. 97-103, 2008.1023-3830http://hdl.handle.net/11449/39908Objective and design: We have previously reported a role for annexin-A1 in liver proliferation and tumorogenicity as well as its action as an acute phase protein in a model of endotoxemia in interleukin-6 null mice.Material and methods: In this study, we have investigated the analysis of the gene and protein expression in annexin-A1 null mice and the wild type livers during foetal and adult life, and in the presence of a proinflammatory stimulus.Results: The data indicate a link between the expression of the annexin-A1 as serine-phosphorylated-protein during early events of the inflammatory response and as tyrosine-phosphorylated-form at later time-points, during the resolution of inflammation.Conclusions: The study of annexin-A1 post-translation modification may promote a new annexin-A1 peptide discovery programme to treat specific pathologies.97-103enghepatocytesNeutrophilLiverInflammationGene expressionArtigo10.1007/s00011-007-7114-2WOS:000254436500002Acesso restrito5102737730539655