Holland, Roberto [UNESP]Souza, Valdir de [UNESP]Nery, Mauro Juvenal [UNESP]Faraco Júnior, Italo MedeirosBernabé, Pedro Felício Estrada [UNESP]Otoboni Filho, José Arlindo [UNESP]Dezan Júnior, Eloi [UNESP]2014-05-272014-05-272001-02-08Brazilian dental journal, v. 12, n. 1, p. 3-8, 2001.0103-6440http://hdl.handle.net/11449/66463The subject of this study was to observe the rat subcutaneous connective tissue reaction to implanted dentin tubes filled with mineral trioxide aggregate, Portland cement or calcium hydroxide. The animals were sacrificed after 7 or 30 days and the undecalcified specimens were prepared for histological analysis with polarized light and Von Kossa technique for mineralized tissues. The results were similar for the studied materials. At the tube openings, there were Von Kossa-positive granules that were birefringent to polarized light. Next to these granulations, there was an irregular tissue like a bridge that was Von Kossa-positive. The dentin walls of the tubes exhibited in the tubules a structure highly birefringent to polarized light, usually like a layer and at different depths. The mechanism of action of the studied materials has some similarity.3-8engaluminum derivativecalcium derivativecalcium hydroxidecoloring agentdiagnostic agentfluorescent dyemineral trioxide aggregateoxidesilicatetooth cementanimalcell nucleuschemically induced disorderconnective tissuedentindrug combinationdrug effectfibroblastgiant cellhumanneutrophilpathologypolarization microscopyratskintimetooth pulp diseaseultrastructureAluminum CompoundsAnimalsCalcium CompoundsCalcium HydroxideCell NucleusColoring AgentsConnective TissueDental CementsDentinDentin, SecondaryDrug CombinationsFibroblastsFluorescent DyesGiant CellsHumansMicroscopy, PolarizationNeutrophilsOxidesRatsSilicatesSkinTime FactorsArtigoAcesso aberto2-s2.0-0035234183533464015936172166857713118618918813777272581972