Lima, Rodrigo Fernandes deRodriguez, Daniel Andrés OsórioCampos, Mônica Souza [UNESP]Biancardi, Manoel FranciscoSantos, Iana Figueiredo Ferreira Roriz dosOliveira, Wendyson Duarte deCavasin, Gláucia MariaMarques, Mara RubiaTaboga, Sebastião Roberto [UNESP]Alcantara dos Santos, Fernanda Cristina2015-12-072015-12-072015-10-31Reproductive Toxicology (elmsford, N.y.), v. 58, p. 238–245, 2015.1873-1708http://hdl.handle.net/11449/131676The aim of this study was to evaluate the development of male and female neonatal gerbil prostate under normal conditions and exposed to bisphenol-A (BPA). Normal postnatal development of the female gerbil prostate occurs earlier than and is morphologically distinct from that occurring in males. In BPA-exposed PND8 gerbils, we have not observed evidence of alterations in the ductal branching in either gender. However, the exposure to BPA alters the immunolabeling pattern of AR, ERα, and PCNA. In males, the exposure to high dosages of BPA resulted in a decrease in the proliferative status of the developing ventral prostate. In females, both high and low dosages were sufficient to decrease the proliferation of paraurethral buds in the branching process by more than 50%. Therefore, the obtained data indicate that BPA promotes antiproliferative effects during the neonatal development of the gerbil prostate, with more sensitivity to this endocrine disruptor in females.238–245engAr antagonistsEndocrine-disrupting chemicalsGerbilProstatic morphogenesisArtigo10.1016/j.reprotox.2015.10.016Acesso restrito265291820000-0002-0970-4288