Bosco, Joseane Maria Dias [UNESP]de Oliveira, Sérgio Ricardode [UNESP]Bosco, Álvaro Francisco [UNESP]Schweitzer, Christiane MarieJardim Júnior, Élerson Gaetti [UNESP]2014-05-272014-05-272008-12-01Brazilian Dental Journal, v. 19, n. 2, p. 119-123, 2008.0103-64401806-4760http://hdl.handle.net/11449/70707The aim of the present study was to evaluate the effects of local tetracycline on the occurrence of alveolar osteitis in rats, and on the microbiota associated to this infection. Forty Wistar rats were randomly assigned to 4 groups (n=10): I - the rats had the maxillary right incisor extracted and the alveolar wound did not receive any treatment; II - adrenaline and Ringer-PRAS were introduced into the alveolar wound; III - the alveolar wound was irrigated with sterile saline; and IV - the alveolar wound was irrigated with an aqueous solution of tetracycline. Microbial samples from the alveolar wounds were collected 2 days after surgery and inoculated on blood agar (with and without 8 μg/mL of tetracycline) and other selective media, and were incubated in either aerobiosis or anaerobiosis at 37°C, for 2 to 14 days. It was verified that tetracycline reduced the occurrence of alveolar osteitis in the rats and caused significant changes in the microbiota of the surgical sites, decreasing the number of anaerobes and increasing the participation of tetracycline-resistant and multi-resistant microorganisms.119-123engAlveolar osteitisAntimicrobialsDry alveolusMicroorganismsTetracyclineadrenalinantiinfective agentisotonic solutionRinger's solutiontetracyclineunclassified drugvasoconstrictor agentActinomycesanimalantibiotic resistancebacterial countBacteroidescomparative studydrug effectEnterobacteriaceaeEnterococcusEubacteriumFusobacteriumincisorlavagemalemicrobiologymultidrug resistancePeptostreptococcusrandomizationratsuppurationtooth extractiontooth paintooth socketVeillonellaWistar ratAnimalsAnti-Bacterial AgentsColony Count, MicrobialDrug Resistance, Multiple, BacterialDry SocketEpinephrineIncisorIrrigationIsotonic SolutionsMaleRandom AllocationRatsRats, WistarSuppurationTetracycline ResistanceTooth ExtractionTooth SocketVasoconstrictor AgentsArtigo10.1590/S0103-64402008000200006S0103-64402008000200006Acesso aberto2-s2.0-614493462302-s2.0-61449346230.pdf9831236034935598460599251258246400011553552103270000-0001-9561-8281