Bolzani, Vanderlan da Silva [UNESP]Valli, Marilia [UNESP]Pivatto, Marcos [UNESP]Viegas, Claudio2014-05-202014-05-202012-01-01Pure and Applied Chemistry. Res Triangle Pk: Int Union Pure Applied Chemistry, v. 84, n. 9, p. 1837-1846, 2012.0033-4545http://hdl.handle.net/11449/26071Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors.1837-1846engBrazilian biomesdrug discoverymedicinal chemistrynatural productstropical biodiversityArtigo10.1351/PAC-CON-12-01-11WOS:000307817300002Acesso restrito4484083685251673