Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.

Carvalho, JCTSilva, MFCMaciel, MAMPinto, Abedala Derbli [UNESP]Nunes, D. S.Lima, R. M.Bastos, J. K.Sarti, S. J.2014-05-202014-05-201996-10-01Planta Medica. Stuttgart: Georg Thieme Verlag, v. 62, n. 5, p. 402-404, 1996.0032-0943http://hdl.handle.net/11449/39058The anti-inflammatory and antinociceptive effects of trans-dehydrocrotonin, isolated from the bark of Croton cajucara (Euphorbiaceae), were investigated using several animal models. The trans-dehydrocrotonin produced a significant inhibition of carrageenin-induced paw edema and cotton pellet granuloma in rats. It also inhibited the writhings in mice induced by acetic acid, but did not show a significant effect in the hot-plate test in mice. The LD(50) of t-DCTN was 555.0 mg/kg (p.o.) for mice.402-404engCroton cajucaraEuphorbiaceaetrans-dehydrocrotonin19-nor-clerodane diterpeneanti-inflammatory and antinociceptiveInvestigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara .1.Artigo10.1055/s-2006-957925WOS:A1996VQ03600004Acesso restrito