Cabrera, Flavio C. [UNESP]Melo, Antonio F. A. A.Souza, Joao C. P. deJob, Aldo E. [UNESP]Crespilho, Frank N.2015-10-212015-10-212015-01-01Lab On A Chip, v. 15, n. 8, p. 1835-1841, 2015.1473-0197http://hdl.handle.net/11449/129322Magnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.1835-1841engArtigo10.1039/c4lc01483aWOS:000352088400005Acesso restrito