Gomes, Greici Cristiani [UNESP]Salgado, Hérida Regina Nunes [UNESP]2022-04-292022-04-292006-01-01Journal of AOAC International, v. 89, n. 4, p. 1077-1079, 2006.1060-3271http://hdl.handle.net/11449/231800The validation of a microbiological assay, applying cylinder plate method for determination of the activity of lomefloxacin in coated tablets is described. Using a strain of Bacillus subtilis ATCC 9372 as the test organism, lomefloxacin was measured in concentrations ranging from 2.0 to 8.0 μg/mL. The method validation showed that it is linear (r= 0.9999), precise (relative standard deviation = 1.15%), and accurate (it measured the added quantities). The excipients did not interfere in the determination. It was concluded that the microbiological assay is satisfactory for quantitation of lomefloxacin in tablets.1077-1079engArtigo10.1093/jaoac/89.4.10772-s2.0-33750694271