Sousa, N.Anicchino-Bizzacchi, J. M.Leite, E. M.Locatelli, M. F.Albuquerque, D.Costa, F. F.Castro, M. L.2014-05-202014-05-202005-01-01Vox Sanguinis. Oxford: Blackwell Publishing Ltd, v. 88, n. 1, p. 31-34, 2005.0042-9007http://hdl.handle.net/11449/7561Background and Objectives B subgroups are rare and the genetic analysis reported to date has been limited.Materials and Methods Serological and molecular investigations were performed in blood from a B-subgroup donor.Results Red cells did not react with anti-B and anti-AB reagents. However, cells absorbed anti-B. Red cells presented positive reactions with anti-H, and saliva secreted H substance. The molecular study demonstrated a B allele with the substitutions 467C>T, 646T>A, 681G>A, 771C>T, 796C>A, 803G>C, 829G>A and an 0 allele with the sequence of 002.Conclusions It is probable that the presence in exon 7 of some of the 002 substitutions could have weakened the enzymatic activity of the encoded B transferase.31-34engABOB subgroupblood groupgenotypingmolecular biologyArtigo10.1111/j.1423-0410.2005.00583.xWOS:000226931200005Acesso restrito