de Andrade-Neto, Valter F.da Silva, TitoXavier Lopes, Lucia M.do Rosario, Virgilio E.de Pilla Varotti, FernandoKrettli, Antoniana U.2014-05-202014-05-202007-07-01Antimicrobial Agents and Chemotherapy. Washington: Amer Soc Microbiology, v. 51, n. 7, p. 2346-2350, 2007.0066-4804http://hdl.handle.net/11449/35268Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7 ' R,8S,8 ' S)-3 ',4 '-methylenedioxy-4,5-dimethoxy-2,7 '-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of <= 0.32 mu M. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.2346-2350engArtigo10.1128/AAC.01344-06WOS:000247665800008Acesso abertoWOS000247665800008.pdf