Barrow, PaulLovell, MargaretBerchieri Jr., Angelo [UNESP]2014-05-272014-05-271998-06-10Clinical and Diagnostic Laboratory Immunology, v. 5, n. 3, p. 294-298, 1998.1071-412Xhttp://hdl.handle.net/11449/65457A lytic bacteriophage, which was previously isolated from sewage and which attaches to the K1 capsular antigen, has been used to prevent septicemia and a meningitis-like infection in chickens caused by a K1+ bacteremic strain of Escherichia coli. Protection was obtained even when administration of the phage was delayed until signs of disease appeared. The phage was able to multiply in the blood. In newly borne colostrum-deprived calves given the E. coli orally, intramuscular inoculation of phage delayed appearance of the bacterium in the blood and lengthened life span. With some provisos there is considerable potential for this approach to bacterial-disease therapy.294-298engantiinfective agentanimal experimentbacteriophagecattlechickencontrolled studyescherichia coliintramuscular drug administrationlytic bacteriophagemeningitismortalitynonhumanpriority journalsepticemiasewageAnimalsBacteremiaCattleCattle DiseasesChickensColiphagesEscherichia coliEscherichia coli InfectionsMeningitis, BacterialPoultry DiseasesSpecific Pathogen-Free OrganismsArtigoWOS:000073471300005Acesso restrito2-s2.0-0031804082