Mello, MLSBarbisan, L. F.Lareef, M. H.Russo, J.Vidal, B. D.2014-05-202014-05-202004-02-26Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 546, n. 1-2, p. 39-43, 2004.0027-5107http://hdl.handle.net/11449/18417The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms. (C) 2003 Elsevier B.V. All rights reserved.39-43engapoptosiscatastrophic deathhuman breast epithelial cellschromosome 11chromosome 17Artigo10.1016/j.mrfmmm.2003.10.005WOS:000188838800005Acesso restrito3278528112652257