Cardoso, Rosilene FressattiCardoso, Marco AntonioLeite, Clarice Queico Fujimura [UNESP]Sato, Daisy NakamuraMamizuka, Elsa MasaeHirata, Rosário Dominguez CrespoMello, Fernando Fiúza deHirata, Mario Hiroyuki2014-05-202014-05-202007-02-01Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 102, n. 1, p. 59-61, 2007.0074-0276http://hdl.handle.net/11449/27216Resistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG) , and within the inhA promoter and/or in structural gene. A small percentage (~ 10%) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh) . Here we report the detection of two ndh locus mutations (CGT to TGT change in codon 13 and GTG to GCG change in codon 18) by analyzing 23 INH-resistant and in none of 13 susceptible isolates from Brazilian tuberculosis patients. We also detected two isolates without a mutation in ndh, or any of the other INH resistance-associated loci examined, suggesting the existence of additional, as yet to be described, INH resistance mechanisms.59-61engMycobacterium tuberculosisNADH dehydrogenase geneisoniazid resistanceArtigo10.1590/S0074-02762007000100009S0074-02762007000100009Acesso abertoS0074-02762007000100009.pdf2114570774349859