Rezende, Tiago M. [UNESP]Sponton, Carlos H.G. [UNESP]Malagrino, Pamella A. [UNESP]Bezerra, Marcos A.C.Penteado, Carla F.F.Zanesco, Angelina [UNESP]2014-05-272014-05-272011-12-01Archives of Physiology and Biochemistry, v. 117, n. 5, p. 265-269, 2011.1381-34551744-4160http://hdl.handle.net/11449/72899Context: Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO). Objective: To evaluate if women with eNOS gene polymorphism at position-G894T would be less responsive to EX than those who did not carry T allele. Methods: Women were trained 3 days/week, 40 minutes session during 6 months. Cardio-biochemical parameters and genetic analysis were performed in a double-blind fashion. Results: Plasma NOx - levels were similar in both groups at baseline (GG genotype: 18.44±3.28 μM) and (GT + TT genotype: 17.19±2.43 μM) and after EX (GG: 29.20±4.33 and GT+TT: 27.38±3.12 μM). A decrease in blood pressure was also observed in both groups. Discussion and conclusion: The presence of eNOS polymorphism does not affect the beneficial effects of EX in women. © 2011 Informa UK, Ltd.265-269engBlood pressureNitric oxidePhysical trainingWomenendothelial nitric oxide synthasenitric oxideNOS3 protein, humanallelebiosynthesisbloodblood pressureBrazilcardiovascular diseasecase control studydouble blind procedureenzymologyexercisefemalegene frequencygeneticsgenotypehumanmiddle agedsingle nucleotide polymorphismAllelesBlood PressureCardiovascular DiseasesCase-Control StudiesDouble-Blind MethodExerciseFemaleGene FrequencyGenotypeHumansMiddle AgedNitric OxideNitric Oxide Synthase Type IIIPolymorphism, Single NucleotideArtigo10.3109/13813455.2011.596548Acesso restrito2-s2.0-824551717664472007237545596