Saad, W. A.Camargo, L. A A2014-05-262014-05-261984-01-01Pharmacology, v. 28, n. 4, p. 228-234, 1984.0031-7012http://hdl.handle.net/11449/63648The effects of sodium and potassium excretion after intrahypothalamic administration of two α-adrenoceptor agonists and the effect of α-adrenoceptor antagonists were studied in groups of rats. Prazosin was equally effective at blocking the natriuretic and kaliuretic responses to the α1-adrenoceptor agonist phenylephrine and the mixed α1/α2-adrenoceptor agonist noradrenaline, while yohimbine which acts preferentially on α2-adrenoceptors was effective in potentiating these responses. These results suggest the presence of two types of α-adrenoceptors for the modulation of ventromedial hypothalamic pathways that interfere with the regulation of the two cations: stimulation of α1-adrenoceptors facilitates, while stimulation of α2-adrenoceptors inhibits the excretion of the ions.228-234engalpha 1 adrenergic receptoralpha 2 adrenergic receptoralpha adrenergic receptor stimulating agentnoradrenalinphenylephrineprazosinyohimbineanimal experimentcentral nervous systemkidneynonhumanpotassium urine levelratsodium urine levelzona incertaAdrenergic alpha-AgonistsAdrenergic alpha-AntagonistsAnimalDogsDose-Response Relationship, DrugHypothalamus, MiddleNorepinephrinePhenylephrinePotassiumPrazosinRabbitsRatsSodiumSupport, Non-U.S. Gov'tYohimbineEffects of the application of α1- and α2-adrenoceptor agonists and antagonists into the ventromedial hypothalamus on the sodium and potassium renal excretionArtigo10.1159/000137967Acesso restrito2-s2.0-0021362154