Batista, Isabelle V.Lanz, Marcos R. V.Dias, Iara L. T.Tanaka, Sonia M. C. N.Tanaka, Auro A.Sotomayor, Maria Del Pilar Taboada [UNESP]2014-05-202014-05-202008-01-01Analyst. Cambridge: Royal Soc Chemistry, v. 133, n. 12, p. 1692-1699, 2008.0003-2654http://hdl.handle.net/11449/41899This work reports the use of iron tetrapyridinoporphyrazine (FeTPyPz) as a highly selective catalyst in the construction of an electrochemical sensor for estradiol valerate (EV) determination. The sensor was prepared by modifying a carbon paste with FeTPyPz. The best results were obtained in a mixture of acetonitrile (MeCN) and 0.1 mol L(-1) phosphate buffer solution (pH 6.0) in a volume ratio of 47 : 53. A linear response range was observed between 45 and 450 mmol L(-1) with a sensitivity of 12160 +/- 306 mu A L mol(-1) and quantification and detection limits of 45 and 13 mmol L(-1), respectively. The repeatability, expressed as the relative standard deviation (RSD) for n = 10, was 5.9% ([EV] = 50 mu mol(-1)). The reproducibility (RSD) for the sensor construction was better than 4% and the operational stability (RSD) over 50 measurements was 1.8%. A detailed investigation regarding the selectivity and electrochemical characteristics was carried out. Finally, in a first step to evaluate the application potential of the sensor, it was successfully applied to determine EV in a commercial formulation.1692-1699engArtigo10.1039/b804462gWOS:000261005100007Acesso restrito2933194342093387