Oliveira, Leandro Gustavo de [UNESP]Câmara, Niels Olsen S.Peraçoli, José Carlos [UNESP]Peraçoli, Maria Terezinha Serrão [UNESP]Moron, Antonio F.Sass, Nelson2014-05-272014-05-272011-04-01Pregnancy Hypertension, v. 1, n. 2, p. 129-131, 2011.2210-7789http://hdl.handle.net/11449/72349Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5 pg/mL in preeclamptic women, as compared with 52.28 pg/mL in the controls (P = 0.0028). The mean serum level of sFlt-1 was 13,636 pg/mL in preeclamptic women, as compared with 2020 pg/mL in the controls (P < 0.0001). PlGF levels were significantly lower in women with preeclampsia. © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.129-131engAngiogenic factorsInflammationIP-10PlGFPreeclampsiasFlt-1gamma interferon inducible protein 10placental growth factorvasculotropin receptor 1adultchemoluminescenceclinical articlecontrolled studycytometryfemalehumanhypothesisimmunoassayinflammationpathogenesispreeclampsiaprotein blood levelArtigo10.1016/j.preghy.2011.02.002Acesso restrito2-s2.0-79952655899849943738159561407207948203259136486557387397806