Nogueira, Matheus Carvalho AlvesNobre, VandackPires, Magda CarvalhoRamos, Lucas Emanuel FerreiraRibeiro, Yara Cristina Neves Marques BarbosaAguiar, Rubia Laura OliveiraVigil, Flavia Maria BorgesGomes, Virginia Mara ReisSantos, Camila de OliveiraMiranda, Davi MesquitaDurães, Pamela Andrea AlvesCosta, Josiane Moreira daSchwarzbold, Alexandre VargasGomes, Angélica Gomides dos ReisPessoa, Bruno PortoMatos, Carolina CunhaCimini, Christiane Corrêa RodriguesCarvalho, Cíntia Alcântara dePonce, Daniela [UNESP]Manenti, Euler Roberto FernandesCenci, Evelin Paola de AlmeidaAnschau, FernandoCosta, Flávia Carvalho CardosoNascimento, Francine Janaina MagalhãesBartolazzi, FredericoGrizende, Genna Maira SantosVianna, Heloisa ReniersNepomuceno, Jomar CristeliRuschel, Karen Brasil [UNESP]Zandoná, Liege BarellaCastro, Luís César deSouza, Maíra DiasCarneiro, MarceloBicalho, Maria Aparecida CamargosVilaça, Mariana do NascimentoBonardi, Naiara Patrícia FagundesOliveira, Neimy Ramos deLutkmeier, RaquelFrancisco, Saionara CristinaAraújo, Silvia FerreiraDelfino-Pereira, PoliannaMarcolino, Milena Soriano2023-07-292023-07-292023-01-01Frontiers in Medicine, v. 10.2296-858Xhttp://hdl.handle.net/11449/247411Objectives: To assess the ABC2-SPH score in predicting COVID-19 in-hospital mortality, during intensive care unit (ICU) admission, and to compare its performance with other scores (SOFA, SAPS-3, NEWS2, 4C Mortality Score, SOARS, CURB-65, modified CHA2DS2-VASc, and a novel severity score). Materials and methods: Consecutive patients (≥ 18 years) with laboratory-confirmed COVID-19 admitted to ICUs of 25 hospitals, located in 17 Brazilian cities, from October 2020 to March 2022, were included. Overall performance of the scores was evaluated using the Brier score. ABC2-SPH was used as the reference score, and comparisons between ABC2-SPH and the other scores were performed by using the Bonferroni method of correction. The primary outcome was in-hospital mortality. Results: ABC2-SPH had an area under the curve of 0.716 (95% CI 0.693–0.738), significantly higher than CURB-65, SOFA, NEWS2, SOARS, and modified CHA2DS2-VASc scores. There was no statistically significant difference between ABC2-SPH and SAPS-3, 4C Mortality Score, and the novel severity score. Conclusion: ABC2-SPH was superior to other risk scores, but it still did not demonstrate an excellent predictive ability for mortality in critically ill COVID-19 patients. Our results indicate the need to develop a new score, for this subset of patients.engCOVID-19intensive care unitmortalityprognosisrisk scoresSARS-CoV-2Artigo10.3389/fmed.2023.11302182-s2.0-85159894252