Itoyama, M. M. [UNESP]De Campos Bicudo, H. E.M. [UNESP]Manzato, A. J. [UNESP]2022-04-282022-04-281998-12-01Cytobios, v. 1998, n. 382, p. 81-93, 1998.0011-4529http://hdl.handle.net/11449/224098The productivity of Drosophila prosaltans treated with six concentrations of caffeine (from 50 μg/ml to 2,500 μg/ml of culture medium) during ten generations (∼8 months) decreased in a dosage dependent manner in every generation, but at the end of the treatment the flies in all experiments recovered normal productivity, except for those treated with 2,500 μg/ml. Longevity in the tenth generation was significantly reduced in males and females only in the 2,500 μg/ml dosage, with males being much more affected than females. In a previous study in which the treatment was done in a single generation, productivity exhibited only a partial recovery when the treatment ceased and longevity was significantly reduced in 1,500 μg/ml dosages. The hypothesis of selection occurring in ten generations leading to recovery in productivity and to a reduction in the processes which cause a decrease in longevity is being considered.81-93engCaffeineDrosophilaLongevityProductivityArtigo2-s2.0-0032249253