Bolzani, Vanderlan da Silva [UNESP]Gunatilaka, A. A. LeslieKingston, David G. I.2014-05-272014-05-271995-12-01Journal of Natural Products, v. 58, n. 11, p. 1683-1688, 1995.0163-3864http://hdl.handle.net/11449/64664Bioactivity-guided fractionation of a methanolic CHCl 3 extract of the leaves of Pterogyne nitens afforded the known guanidine alkaloid pterogynidine [2] and three new guanidine alkaloids, nitensidines A [3], B [4], and C [5], all of which exhibited selective activity towards the DNA repair-deficient yeast mutant RS 321 (IC 12=9.3-20.0 μg/ml); 3,4, and 5 were moderately cytotoxic to CHO Aux B 1 cells (IC 50=8.5-13.0 μg/ml).1683-1688engguanidine derivativenitensidinepterogynidinepterogynineunclassified drugantineoplastic activitybioassaycarbon nuclear magnetic resonancecytotoxicitydna repairdrug activitydrug isolationdrug structureproton nuclear magnetic resonanceArtigo10.1021/np50125a006WOS:A1995TQ55100006Acesso restrito2-s2.0-00296109794484083685251673