Tommasini Grotto, Rejane Maria [UNESP]Cantao, Natalia Mirele [UNESP]Padovani, Juliana Lara [UNESP]Souza, Lenice do Rosario de [UNESP]Silva, Giovanni Faria [UNESP]Ferrasi, Adriana Camargo [UNESP]Moura Campos Pardini, Maria Ines de [UNESP]2018-11-262018-11-262016-07-01Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 49, n. 4, p. 491-493, 2016.0037-8682http://hdl.handle.net/11449/161869Introduction: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.491-493engHepatitis C virusHuman platelets antigen polymorphismsHuman immunodeficiency virusArtigo10.1590/0037-8682-0105-2016S0037-86822016000400491WOS:000382457200015Acesso abertoS0037-86822016000400491.pdf358789508522622450205598265681820000-0001-9200-53910000-0003-1948-5071