Danieletto, Carolina Ferrairo [UNESP]Ferreira, Gustavo ZannaFarah, Gustavo JacobucciCuman, Roberto Kenji Nakamura2018-12-112018-12-112017-01-01Special Care in Dentistry, v. 37, n. 1, p. 38-42, 2017.1754-45050275-1879http://hdl.handle.net/11449/168553Introduction: Thrombocytopenia is the reduction in the number of blood ­platelets, which may be caused by ­several different conditions such as sepsis, disseminated intravascular ­clotting, and large blood losses. Additionally, in rare situations, thrombocytopenia may also be induced by the use of medicaments. One of these drugs is the vancomycin, a glycopeptide presently used against ­serious infections involving Gram-positive bacteria such as the methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus. Objective: The objective of this study is to report on a case of serious vancomycin-induced thrombocytopenia in a patient infected with methicillin-resistant S. aureus after mandibular reconstruction with autogenous bone graft, and to draw attention to the importance of this clinically rare adverse effect. Conclusion: Vancomycin-induced thrombocytopenia is a rare condition, which is also a significant disorder that demands attention and the rapid identification and replacement of the antimicrobial agent.38-42engantibacterialbone graftthrombocytopeniavancomycinArtigo10.1111/scd.12182Acesso restrito2-s2.0-84962815202