Paiva, Sergio Alberto Rupp de [UNESP]Yeum, K. J.Lee, K. S.Park, I. S.Lee-Kim, Y. C.Russell, R. M.2014-05-272014-05-271999-12-01Asia Pacific Journal of Clinical Nutrition, v. 8, n. 2, p. 160-166, 1999.0964-7058http://hdl.handle.net/11449/65928Carotenoid concentrations were measured in serum and in both non-cancerous and cancerous gastric mucosal tissues of Korean patients with gastric cancer (n = 18). Carotenoids in serum and gastric tissue were extracted with chloroform/methanol (2:1), and measured using reverse-phase high-performance liquid chromatography with a C30 column. Cryptoxanthin and β-carotene were the major carotenoids in the Korean blood and they had a median ratio of non-cancerous tissue/serum levels which was less than 1.0. No significant differences of Cryptoxanthin and β-carotene levels were found between non-cancerous and cancerous tissues. After incubation of β-carotene with gastric tissue, significantly higher levels of β-carotene breakdown products were produced in the homogenates of cancerous tissue when compared with non-cancerous tissue. Lutein, zeaxanthin and α-carotene were the minor carotenoid constituents in the blood and their median ratio of non-cancerous tissue/serum levels was greater than 1.0. Cancerous tissue had significantly lower levels of lutein, zeaxanthin and α-carotene than did non-cancerous tissue. It appears that the increased breakdown of β-carotene and cryptoxanthin in cancerous tissue can be compensated for by an increased uptake of circulating carotenoids by cancerous tissue, whereas lutein, zeaxanthin and α-carotene levels in cancerous tissue are not able to be maintained.160-166engβ-caroteneCarotenoidsCryptoxanthinGastric cancerKoreaLycopeneMucosaSerumArtigo10.1046/j.1440-6047.1999.00087.xAcesso restrito2-s2.0-24044515580