Calvo, Tamara Regina [UNESP]Demarco, DiegoSantos, Fabio V. [UNESP]Moraes, Helen P. [UNESP]Bauab, Tais M. [UNESP]Varanda, Eliana Aparecida [UNESP]Colus, Ilce M. S.Vilegas, Wagner [UNESP]2014-05-202014-05-202010-08-01Natural Product Communications. Westerville: Natural Products Inc, v. 5, n. 8, p. 1225-1232, 2010.1934-578Xhttp://hdl.handle.net/11449/7470Phenolic compounds are produced by secretory idioblasts and hypodermis, and by specialized cells of the epidermis and chlorenchyma of leaves of Alchornea triplinervia. Phytochemical investigation of these leaves led to the isolation of the known substances quercetin, quercetin-7-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-alpha-L-arabinopyranoside, amentoflavone, brevifolin carboxylic acid, gallic acid, and methyl gallate from the methanolic extract, and stigmasterol, campesterol, sitosterol, lupeol, friedelan-3-ol, and friedelan-3-one from the chloroform extract. In studies of antibacterial activity and mutagenicity, the methanolic extract showed promising activity against Staphylococcus aureus (MIC=62.5 mu g/mL) and was slightly mutagenic in vitro and in vivo at the highest concentrations tested (1335 mg/kg b.w.).1225-1232engAlchornea triplinerviaflavonoidsantibacterial activitymutagenicitysecretory structuresArtigoWOS:000281074200016Acesso restrito0000-0003-3032-2556