Goncalves, Amanda Costa [UNESP]Geraldo Maia, Danielle Cardoso [UNESP]Ferreira, Lucas Souza [UNESP]Silva Monnazzi, Luis Gustavo [UNESP]Alegranci, Pamela [UNESP]Polesi Placeres, Marisa Campos [UNESP]Batista-Duharte, Alexander [UNESP]Carlos, Iracilda Zeppone [UNESP]2015-10-212015-10-212015-02-01Mycopathologia, v. 179, n. 1-2, p. 21-30, 2015.0301-486Xhttp://hdl.handle.net/11449/129359Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall major components over the cytosolic oligo-merization domain (NOD)-like receptors, important regulators of inflammation and responsible for the maturation of IL-1 beta and IL-18, whose functions are dependents of the caspase-1 activation, that can participate of inflammasome. It was evaluated the percentage of activation of caspase-1, the production of IL-1 beta, IL-18, IL-17, IFN-gamma and nitric oxide in a Balb/c model of S. schenckii infection. It was observed a decreased activity of caspase-1 during the fourth and sixth weeks of infection accompanied by reduced secretion of the cytokines IL-1 beta, IL-18 and IL-17 and high production of nitric oxide. IFN-gamma levels were elevated during the entire time course of infection. This temporal reduction in caspase-1 activity coincides exactly with the reported period of fungal burden associated with a transitory immunosuppression induced by this fungus and detected in similar infection models. These results indicate the importance of interaction between caspase-1, cytokines IL-1 beta and IL-18 in the host defense against S. schenckii infection, suggesting a participation the inflammasome in this response.21-30engCytokinesCaspase-1Nitric oxideSporothrix schenckiiArtigo10.1007/s11046-014-9810-0WOS:000349528700003Acesso restrito1730146818754269