Soares, Milena Botelho PereiraLima, Ricardo Santana deRocha, Leonardo LimaVasconcelos, Juliana FragaRogatto, Silvia Regina [UNESP]Santos, Ricardo Ribeiro dosIacobas, SandaGoldenberg, Regina CoeliIacobas, Dumitru AndreiTanowitz, Herbert BernardCarvalho, Antonio Carlos Campos deSpray, David Conover2014-05-272014-05-272010-08-01Journal of Infectious Diseases, v. 202, n. 3, p. 416-426, 2010.0022-1899http://hdl.handle.net/11449/71798Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart.We performed an extensive microarray analysis of hearts from a mouse model of this disease and identified significant alterations in expression of ~12% of the sampled genes. Extensive up-regulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins, and major histocompatibility complex molecules) and fibrosis (extracellular matrix components, lysyl oxidase, and tissue inhibitor of metalloproteinase 1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide newtherapeutic targets in chronic Chagas disease. © 2010 by the Infectious Diseases Society of America.416-426engactin binding proteinbeta3 integrincathepsincathepsin Hcathepsin SCD11b antigenCD38 antigenCD4 antigenCD52 antigenCD8 antigencell adhesion moleculecell surface proteinchemokinechemokine receptorchlordanecytokine receptorgalectin 3gamma interferonintercellular adhesion molecule 1interleukin 10 receptor alphamatrix metalloproteinase 14metalloproteinase inhibitorPADGEM proteinprotein lysine 6 oxidasetumor necrosis factor alphaanimal cellanimal experimentanimal modelanimal tissuecell proliferationChagas diseasechronic diseasecontrolled studyfemalegene expressionheart failureheart muscleheart muscle fibrosishistocompatibility compleximmune responseimmune response geneimmunohistochemistryinflammationintracellular signalingmalemicroarray analysismousemyocarditisnonhumannucleotide sequencepathogenesisphosphate transportpriority journalTrypanosoma cruziupregulationArtigo10.1086/653481Acesso restrito2-s2.0-779547386412259986546265579