Camargo, João Lauro Viana de [UNESP]2014-05-272014-05-272010-08-25Asian Pacific Journal of Cancer Prevention, v. 11, n. 1, p. 7-8, 2010.1513-7368http://hdl.handle.net/11449/71833In 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. The protocol adopted by IBAMA was a modification of the one originally proposed by researchers led by Nobuyuki Ito, from the Nagoya City University Medical School. Among the modifications established in the Brazilian protocol were the use of both sexes of the outbreed Wistar strain of rats and two positive control test chemicals. The adoption of the modified DMBDD protocol was instrumental during the last decade for qualifying technical people and to spread knowledge on chemical carcinogenesis in Brazil.7-8engCell proliferationEstrogenImmunosuppressionMutagen/carcinogen screeningTwo-year bioassaycarcinogenanimalantibody specificitybioassayBrazilcarcinogen testingchemically induced disorderconference paperdrug effectexperimental neoplasmfemaleFischer 344 ratgovernment regulationmalepathologyratstandardAnimalsBiological AssayCarcinogenicity TestsCarcinogensFemaleGovernment RegulationMaleNeoplasms, ExperimentalOrgan SpecificityRatsRats, Inbred F344Trabalho apresentado em eventoAcesso aberto2-s2.0-779558108082-s2.0-77955810808.pdf