Nogueira, L�lian [UNESP]Mello, Danielle FerrazTrevisan, RafaelGarcia, Danielly [UNESP]da Silva Acosta, DaianeDafre, Alcir Luizde Almeida, Eduardo Alves [UNESP]2018-12-112018-12-112017-01-01Marine Environmental Research, v. 126, p. 109-115.1879-02910141-1136http://hdl.handle.net/11449/174289This study investigated the effects of hypoxia on oxidative stress response and immune function in mussels Perna perna exposed to air for 6, 12, 24 and 48�h. In air-exposed mussels, the antioxidant enzymes superoxide dismutase (SOD), catalase, and glutathione reductase (GR) activities were lower in gill tissues (24–48�h) and digestive gland (12�h), while the glutathione peroxidase and GR activities were increased in the digestive gland (48�h). In both tissues, aerial exposure promoted a rapid (6�h) and persistent (up to 48�h) increase of glutathione levels. Decreased hemocyte count and viability, as well as increased phagocytic activity and cellular adhesion capacity were detected after prolonged aerial exposure (>12�h). In summary, induction of thiol pools, altered antioxidant enzyme activities, and activation of immune responses were detected in hypoxia exposed brown mussels, indicating hypoxia induced tissue-specific responses in both antioxidant and immune systems.109-115engAntioxidant defensesBivalvesHemocytesImmune systemReduced oxygen levelsArtigo10.1016/j.marenvres.2017.02.009Acesso aberto2-s2.0-850143861442-s2.0-85014386144.pdf